2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
CAS: 290297-26-6
Molecular Formula: C30H32F6N4O
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3- - Names and Identifiers
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3- - Physico-chemical Properties
| Molecular Formula | C30H32F6N4O |
| Molar Mass | 578.59 |
| Density | 1.255 |
| Melting Point | 156.2-160.0 °C |
| Boling Point | 597.4±50.0 °C(Predicted) |
| Flash Point | 315.1°C |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 3.09E-14mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 7.89±0.38(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.539 |
| In vitro study | In CHO NK1 cells, netuitant concentration-dependently antagonized the stimulatory effect of substance P (SP). In cells that express the NK2 or NK3 receptor, netuitant has no activity. |
| In vivo study | Netuitant is a brain-permeable, orally active, selective NK1 antagonist. In mice, intrathecal administration of Substance P(SP) elicits grasping, biting, licking and other responses, whereas intraperitoneal injection of 1-10 mg/kg of netupite inhibited these responses in a concentration-dependent manner. In gerbils, the podiatric behavior induced by intracerebroventricular injection of NK1 agonists can be counteracted by intraperitoneal injection or oral administration of netuptant. In gerbils, netupite had a long-lasting effect. |
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.728 ml | 8.642 ml | 17.283 ml |
| 5 mM | 0.346 ml | 1.728 ml | 3.457 ml |
| 10 mM | 0.173 ml | 0.864 ml | 1.728 ml |
| 5 mM | 0.035 ml | 0.173 ml | 0.346 ml |
Last Update：2024-01-02 23:10:35
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3- - Reference Information
| use | nytopitan is an effective selective neurokinin -1 receptor (NK1) receptor antagonist. It is achiral and orally active. |
| biological activity | Netupitant (CID6451149) is a selective neurokinin 1(NK1) receptor antagonist with potential antiemetic activity. |
| target | TargetValue Neurokinin-1 receptor |
| Target | Value |
| In vitro study | In CHO NK1 cells, the stimulation effect of substance P (SP) was antagonized Netupitant concentration-dependent. In cells expressing NK2 or NK3 receptors, Netupitant were inactive. |
| in vivo research | Netupitant is a selective NK1 antagonist that can penetrate through the brain and has oral activity. In mice, intrathecal injection of Substance P(SP) can cause scratching, biting and licking reactions, while intraperitoneal injection of 1-10 mg/kg Netupitant can inhibit these reactions in a concentration-dependent manner. In gerbils, the foot-raising behavior triggered by intraventricular injection of NK1 agonists can be resisted by intraperitoneal injection or oral Netupitant. In gerbils, Netupitant has a lasting effect. |
Last Update：2024-04-09 21:54:55
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